To examine the possible non-specific effects (NSEs) of the novel COVID-19 vaccines, we reviewed the randomised control trials (RCTs) of mRNA and adenovirus-vector COVID-19 vaccines reporting overall mortality, including COVID-19 deaths, accident deaths, cardiovascular deaths and other non-COVID-19 deaths.
For overall mortality, with 74,193 participants and 61 deaths (mRNA:31; placebo:30), the relative risk (RR) for the two mRNA vaccines compared with placebo was 1.03 (95% CI=0.63-1.71).
In the adenovirus-vector vaccines there were 122,164 participants and 46 deaths (vaccine:16; controls:30). The RR for adenovirus-vector vaccines versus placebo/control vaccine was 0.37 (0.19-0.70).
The adenovirus-vector vaccines were associated with protection against COVID-19 deaths (RR=0.11 (0.02-0.87)) and non-accident, non-COVID-19 deaths (RR=0.38 (0.17-0.88)). The two types of vaccines differed significantly with respect to impact on overall mortality (p=0.030) as well as non-accident, non-COVID-19 deaths (p=0.046).
The placebo controlled RCTs of COVID-19 vaccines were halted rapidly due to clear effects on COVID-19 infections. However, the data presented here argue for performing RCTs of mRNA and adeno-vectored vaccines head-to-head comparing long-term effects on overall mortality.
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Thanks NE. I love these decimal figures and TLA's as much as the next person, and it really is great that you show your working, for those that can understand it at a glance. But for the rest of us, If I could ask that yourself and Rudolf Riggery always end your stacks with layman (idiot proof) conclusions like this, that would give me less headaches ;-). Thanks
I´m sorry can I have the pretend I am five year old version? And where is this study getting its numbers from? Cause the Pfizer ones were sXXT.
The mRNA vaccines had no effect on all cause mortality
Thank you.
I do want to say that I am not sure I believe the study. I know one friend who already had a blood clot from the J & J....
Thanks NE. I love these decimal figures and TLA's as much as the next person, and it really is great that you show your working, for those that can understand it at a glance. But for the rest of us, If I could ask that yourself and Rudolf Riggery always end your stacks with layman (idiot proof) conclusions like this, that would give me less headaches ;-). Thanks