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philipat's avatar

It is of course accurate to describe the Janssen and Az-Ox gene therapies as "Viral vectors". But it's equally accurate to refer to them as "DNA gene therapies" which I always do. The manufacturers and Authorities prefer the former term because a) nobody really understands what a viral vector actually is and b) it sounds more "friendly" and much less threatening that a "DNA vaccine".

the other thing that most do not understand is that once inside the cell (via a different delivery vehicle) the viral DNA is transcribed into mRNA and from that point on, the actual mechanism of action is identical to the mRNA therapies. The differenc is only one of delivery.

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Barney Rubble's avatar

I'd say that Astrazeneca agreed to be the "fall guy" for viral vector vaccines in order to promote mRNA tech to the front of the line. I bet a dollar future FOIA disclosures will prove this.

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